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English word obnoxious comes from Latin obnoxius (susceptible to harm), which itself comes from the Latin ob- (towards, facing, against) and noxia (harm, fault, injury). The word acquired its current sense (unplesant) in the 17th century under the influence of the word noxious
ob (Latin)
Against; facing. In the direction of, to, towards. On account of, according to, because of, due to, for (the purpose of).
noxia (Latin)
An injurious act, harm, fault, offence, trespass, wrongdoing, hurt, damage, injury.
obnoxius (Latin)
Susceptible to harm. Vulnerable. Punishable, liable, guilty. Submissive, obedient, compliant. Susceptible to danger, misfortune, or weakness. Obliged, indebted.
obnoxiosus (Latin)
Hurtful, injurious, dangerous; obnoxious. Submissive, subordinate, obedient.
obnoxious (English)
(archaic) exposed to harm or injury.. (preceded by "to feel") Ashamed; acutely aware of one's own offensive qualities.. Extremely unpleasant, offensive, very annoying, odious or contemptible.