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English word topoisomerase comes from English isomerase, English topo- (Place, area or region.)
isomerase (English)
Any enzyme which catalyzes the conversion of one isomeric form of a chemical compound to another.
topo- (English)
Place, area or region.
topoisomerase (English)
(enzyme) Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.